All comics
- Oceanverse
- Octopuns
- octopus pie
- Odd-Fish
- Odd Jobs
- Odd Nauseam
- O''deer
- Odin and Sean
- Odori Park
- Odysseus The Rebel
- Off Campus
- The Off Chance
- Off-White
- of Noobs and Men
- Of Rogues and Robbers
- Of Snakes and Apples
- Of Something and Nothing in Particular
- Of Stars and Swords
- Oglaf
- Ogum
- Oh! Editor-Chan
- OH GOODIE!
- Oh Gosh; a Platinum Nuzlocke
- Oh Joy, Sex Toy
- Oh My Gods!
- O Human Star
- Ojingogo
- Okashina Okashi - Strange Candy
- OK/Cancel
- The Old Crow
- Olde Towne Village Stikfas Players, Ltd
- Old Tyme Gamer
- Old Wizard
- Oleander Kingdom
- The Olympians
- Olympic Dames
- Olympus Overdrive
- Omake Theater
- Omega Manor
- The one adventure of Adelaide Parker
- One Big Word
- One Girl Guy Army
- One-liners
- The One Man Riot
- One Must Break
- One of a Hundred
- One Off
- One of those days
- One Question
- One Sixth Sagas
- One Small Step
- One swoop fell
- One Too Many
- One Zany World
- The Ongoing Adventures of Rocket Llama
- Oni No Noroi
- Only So Much
- On the Bounty
- On the Bright Side
- On The Edge
- On The Edge: Wonderland
- On the Fasttrack
- On the Grind
- Oopsie-doodle
- Open Spaces and Closed Places
- Operations Dance Party
- Ophthalmia
- Opplopolis
- Opposite Attraction
- Optical Overload
- Optimal Clutter
- The Optimist
- The Optimist
- Optipess
- Orange
- Orange Grind
- Orange Junk
- Orange Revolution
- OrAnime
- Orbit