All comics
- Okashina Okashi - Strange Candy
- OK/Cancel
- The Old Crow
- Olde Towne Village Stikfas Players, Ltd
- Old Tyme Gamer
- Old Wizard
- Oleander Kingdom
- The Olympians
- Olympic Dames
- Olympus Overdrive
- Omake Theater
- Omega Manor
- The one adventure of Adelaide Parker
- One Big Word
- One Girl Guy Army
- One-liners
- The One Man Riot
- One Must Break
- One of a Hundred
- One Off
- One of those days
- One Question
- One Sixth Sagas
- One Small Step
- One swoop fell
- One Too Many
- One Zany World
- The Ongoing Adventures of Rocket Llama
- Oni No Noroi
- Only So Much
- On the Bounty
- On the Bright Side
- On The Edge
- On The Edge: Wonderland
- On the Fasttrack
- On the Grind
- Oopsie-doodle
- Open Spaces and Closed Places
- Operations Dance Party
- Ophthalmia
- Opplopolis
- Opposite Attraction
- Optical Overload
- Optimal Clutter
- The Optimist
- The Optimist
- Optipess
- Orange
- Orange Grind
- Orange Junk
- Orange Revolution
- OrAnime
- Orbit
- ORBVS
- Orchard Heroes
- Order of Tales
- Order of the Brick
- The Order of the Stick
- Orenda
- Original Life
- The Original Nutty Funsters
- Oriyan
- Ornery Boy
- Orphiuchus
- Orson
- Oscura
- The Oswald Chronicles
- Otaku -no- Yen
- Otenba Files
- The Other Grey Meat
- Other People's Business
- Other than Swears
- Otherworld
- Otter Soldiers
- Ottocomic
- Our Forever
- Our Future is Red
- Our Home Planet
- Our Intrepid Crew
- Our Last Gasp