All comics
- Operations Dance Party
- Ophthalmia
- Opplopolis
- Opposite Attraction
- Optical Overload
- Optimal Clutter
- The Optimist
- The Optimist
- Optipess
- Orange
- Orange Grind
- Orange Junk
- Orange Revolution
- OrAnime
- Orbit
- ORBVS
- Orchard Heroes
- Order of Tales
- Order of the Brick
- The Order of the Stick
- Orenda
- Original Life
- The Original Nutty Funsters
- Oriyan
- Ornery Boy
- Orphiuchus
- Orson
- Oscura
- The Oswald Chronicles
- Otaku -no- Yen
- Otenba Files
- The Other Grey Meat
- Other People's Business
- Other than Swears
- Otherworld
- Otter Soldiers
- Ottocomic
- Our Forever
- Our Future is Red
- Our Home Planet
- Our Intrepid Crew
- Our Last Gasp
- Our Little Adventure
- Our Super Mom
- Our World
- Out at Home
- The Outer Circle
- Outfoxed
- Outlier
- Out of Character
- Out of Key
- Out of My Element
- Out of World
- Out, out...
- Outrageous Teen Assassin Aiko
- Outrim
- Outsider
- Outta My Head
- Out There
- Out to Get . Me
- Over
- Overcast with a Chance of Doom
- Overcompensating
- Overlord Academy
- Overlord of Ravenfell
- Over the Hedge
- Over The Wall
- Ow My Sanity
- Oxford Clay
- Oxygen Deficient
- Oyster War
- Ozy and Millie
- The Pain
- Pain Train
- Pajama Forest
- Paladins' Haven
- Palandar
- The Pale
- Pale By Comparison
- Palindramas