All comics
- Soup - the Comic Strip
- Southern Cross
- Southern Shed Punk
- The Southern Squadron
- South Pole Strip
- Sovereign
- Soyokaze
- So... You're a Cartoonist?
- So Your Life Is Meaningless
- So Zoo Me!
- Space Avalanche
- The Space Between
- Space Boiz
- Space Brothers
- Space Cat
- Space Goth
- SpaceHunter_X
- Space Jane's Colony
- Spacejinx
- Space Junk
- Spacelsugs
- Space Quest
- Space-Time Condominium
- Spacetrawler
- Spacial
- Spades
- Spaghetti Strap Western
- Spain & Morocco
- Spamusement
- Spare Keys for Strange Doors
- Spare Parts
- Sparkle
- Sparkling Generation Valkyrie Yuuki
- Sparkneedle
- Spazzmoid
- Speak With Monsters
- Spear-Frost
- The Specialists
- Special Level
- Special School
- Spectra
- Spectre
- Speedrun
- Spellcastin' Woman's Rumble
- Spera: Glass Flowers
- SPi
- Spiddrelli
- The Spider Cliff Mysteries
- Spiderwebs
- Spiffy Threads
- Spiked Math
- Spiky-Haired Dragon, Worthless Knight
- Spiky's World
- Spina Cage
- Spindrift
- SPINE
- Spine Blindknot
- Spinks
- Spinnerette
- The Spires
- Spirit Bond
- Spleenal
- The Splendid Everlasting
- Split Lip
- Split Poison
- Spooky Doofus
- Spooner
- Spork
- Sporkman
- SPQR Blues
- Springiette
- Spun Off
- Spy6teen
- Spying with Lana
- Squared Circle Wrestling
- Square Root of Minus Garfield
- Squid Ninja
- Squid Row
- Squid Salad
- Squishy Comics