All comics
- Stupidity in the Right Ear
- Stupid Snake
- Stuporheroes
- SubCulture
- Subculture shock
- Subnormality
- Substitute Class Imago
- Subterforge
- Subterfuge
- The Suburban Jungle
- Suburban Tribe
- Succubus Justice
- Such Rubbish
- Sucker Punch to My Emotions
- Sudden Valley
- Sugar Bits
- Sugarstars
- Sugary Serials
- Suicide for hire
- The Suits
- The Summer of Blake Sinclair
- Sunday Morning Coffee
- The Sundays
- Sundays at 10
- Sunday Smash
- Sun Ev-1
- Sunflower Girl
- Sunny Girl
- Sunset Grill
- Supafine
- Supercrash!
- Supercrash! (French)
- Super Doomed Planet Comics
- SuperFogeys
- Super Frat
- SuperFreaks
- The Super-Gay Adventures of Ross Boston
- SuperLavanderia
- Supermahou
- Supermassive Black Hole A*
- Super Mega
- Supernatural Law
- Supernormal Step
- Supernovas
- Superosity
- Super-Peers
- Super Seed
- Super Stick Man
- Super Stupor
- Super Temps
- Supervillain Psyche
- Super Zeros
- Surfboards and Rayguns
- The Surreal Adventures of Edgar Allan Poo
- Surrealist Obituaries
- Survival Guide
- Survival guide for vaulties
- Surviving Mars
- Surviving the World
- Survivor: The Comic Series
- Suus Animus
- Sverd Shelgr
- Swan Song
- Swashbuckled
- Sweet and Sour Grapes
- Sweet Bro and Hella Jeff
- Sweet Dreams
- Sweet Revenge
- swiftriver
- Sword in Hand
- Swords and Sausages
- Sword & Sarcasm
- Swordwaltzer
- Symbiosis
- Synaptic Misfiring
- Synchronism
- The System
- T3h Pixel
- Table Titans
- TacoFries