Xenobiosis is set on a planet called Arlovia, a planet that is slightly larger than Earth but is very similar in that it has a tilted axis and four distinct seasons. It follows one young girl, Lilith Angelica Vautrin, as she joins in a global struggle to bring justice and recognition to her species, the Celestial Hybrids of Ladrasea, that are half Demon and half Angel. When two human boys, Canan Arion and Asher Rath, sneak into Lilith's hometown trying to evade an angry Demoness, their lives change forever. Not only does a supernatrual force connect Canan, Asher and Lilith as 'soulmates', they will die if they stray too far apart. Canan and Asher then uproot their lives and settle in among Lilith's people and the three begin a long journey in learning about themselves, their people, and what it means to 'belong'.